Analyzing Epigenetic Alterations
Epigenetics is the study of heritable changes in gene activity caused by mechanisms other than DNA sequence changes. Epigenetic analysis research can involve studying alterations in DNA methylation, DNA-protein interactions, chromatin accessibility, histone modifications, and more.
Illumina offers a broad portfolio of next-generation sequencing (NGS)- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying these epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.
A Fuller Picture of Gene Expression Profiling
This eBook discusses genomics applications in gene expression and regulation research. See how RNA-Seq and epigenetic methods provide complementary information.
Key Epigenetic Analysis Techniques
DNA Methylation Analysis
Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.
Learn MoreDNA–Protein Interaction Analysis
Gain insight into protein–DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.
Learn MoreChromatin Accessibility Analysis
Use ATAC-Seq to evaluate regions of open chromatin across the genome. ATAC-Seq can be performed on bulk cell populations or single cells at high resolution.
Learn MoreFeatured Epigenetics Research
Methylome and Clinical Outcomes: An Interview with Dr. Kathleen C. Barnes
In this wide-ranging interview, Dr. Kathleen C. Barnes describes her work as a genetic epidemiologist, how COVID-19 impacted her research plans, and how methylation arrays add another dimension to the study of infectious diseases.
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The Epigenetics of Metastasis
Researchers use methylation arrays and NGS to investigate the epigenetics behind cancer metastasis.
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NGS Proves Invaluable for Biomarker Discovery
Researchers use NGS to study DNA-protein interactions, analyze gene expression, and assess coding exons.
Read ArticleThe Regulatory Landscape of A. thaliana
In plants, chromatin accessibility – the primary mark of regulatory DNA – is relatively static across tissues and conditions. This scarcity of accessible sites that are dynamic or tissue-specific may be due in part to tissue heterogeneity in previous bulk studies.
Join us for this webinar on single-cell ATAC-Seq of Arabidopsis thaliana. The speakers discuss an analytical framework to infer the regulatory networks that govern plant development.
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Related Solutions
Cancer Epigenetics
Studies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. Learn more about epigenetic changes in cancer.
Complex Disease Research
Genome-wide methylation profiling can help researchers understand the mechanisms behind complex diseases. Aberrant methylation has been implicated in complex disorders such as Alzheimer’s disease and asthma. Learn more about complex disease research.
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Additional Resources
Epigenome Roadmap
A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.
Epigenetic Contributions to Addiction
Marilee Morgan discusses the use of NGS to correlate epigenetic signatures with brain image scans of substance abusers.
Nutrition: Matter Over Mind
A review of current research into the impact of epigenetics on human health.
Learn Epigenetics
A SEPA-funded initiative at the Genetic Science Learning Center at the University of Utah.
Nature vs. Nurture
An introduction to epigenetics and the role it plays in cancer, genetic disease, and development.
Methylation Field Guide
A comprehensive guide on array and sequencing-based methylation methods.
Epigenome Blueprint
A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.